NAD+

Cellular Energy & Longevity Support
NAD+ is a coenzyme essential to cellular energy production and mitochondrial function. Levels naturally decline with age, which can impact energy, recovery, and overall cellular performance. Therapeutic NAD+ support is used to promote cellular resilience, improve recovery capacity, and support cognitive and physical performance. It is often incorporated into longevity-focused protocols designed to optimize how the body produces and utilizes energy.
Subscription Plan $299 / every 4 weeks
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Card is authorized after plan selection; you are not charged until a licensed provider approves your plan.

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A Deeper Look Inside NAD+

What is NAD+?

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found in every cell of the body. It plays a central role in cellular energy production through the electron transport chain, DNA repair, and the function of sirtuins; a family of enzymes linked to cellular aging. NAD+ levels decline with age, and compounded NAD+ therapy is used in longevity, cognitive, metabolic, and recovery programs. NAD+ can be administered as a subcutaneous or intramuscular injection, or as an intravenous (IV) infusion, depending on your provider’s protocol. Dose and schedule are individualized. Compounded NAD+ is not FDA-approved for any indication. There are no FDA-approved drug products that deliver NAD+ directly. NAD+ precursor supplements (such as NR and NMN) are regulated as dietary supplements, not drugs. Compounded NAD+ is prepared by state-licensed compounding pharmacies under Section 503A of the Federal Food, Drug, and Cosmetic Act. A valid prescription from a licensed healthcare provider is required for injectable/IV NAD+. Not all applicants qualify. Individual results vary.

The Science

NAD+ is essential for redox reactions in the mitochondria, where it cycles between NAD+ and NADH to drive ATP production. Beyond energy metabolism, NAD+ is a required substrate for sirtuins (involved in longevity and metabolic regulation), PARPs (involved in DNA repair), and CD38 (involved in immune function). NAD+ levels naturally decline with age, chronic stress, alcohol use, and metabolic disease.

Direct clinical data on IV NAD+ is limited. Most supporting evidence comes from studies of NAD+ precursors (nicotinamide riboside, nicotinamide mononucleotide) rather than NAD+ itself. Rapid IV infusion of NAD+ is associated with transient chest pressure, flushing, nausea, and muscle cramps, which are typically minimized by slower infusion rates.

Important Safety Information
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Do not use NAD+ if you:

  • Are pregnant or breastfeeding
  • Have had a prior severe reaction to NAD+ or any infusion ingredient
  • Have active cancer (data are limited; discuss with oncologist)
  • Have severe kidney or liver disease

Tell your provider before starting NAD+ if you:

  • Have cardiovascular disease, arrhythmia, or low blood pressure
  • Have diabetes (NAD+ may affect glucose handling)
  • Have gout or uric acid elevations
  • Take chemotherapeutic agents or immunosuppressants
  • Have a seizure disorder

Common side effects may include: flushing, warmth, nausea, muscle cramps, chest pressure (usually with rapid infusion), fatigue, injection-site discomfort.

Serious but less common risks may include: severe allergic reactions, blood-pressure fluctuations, arrhythmia, worsening of underlying cancer (theoretical, insufficient data), and vasovagal reactions.

This is not a complete list of side effects or contraindications. Compounded NAD+ is not FDA-approved. Long-term safety and efficacy data are limited. Talk to a licensed healthcare provider before starting or continuing NAD+ therapy.

How Revive Longevity Works

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Submit Your Application

Complete a short online wellness quiz so we can understand your goals, health history, and what’s right for you.

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Connect with a Licensed Provider

A healthcare provider reviews your information to determine if you qualify for prescription medication. No waiting rooms, no hassle.

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Begin Your Wellness Journey

If approved, your medication ships directly to your door in as little as 1–2 days; with ongoing support to keep you on track.

Why members choose Revive

Provider-reviewed plans

Every plan is reviewed by a licensed healthcare provider before medication is dispensed.

Medical oversight
Shipped to your door

Medication arrives in discreet packaging on a consistent schedule; no pharmacy trips required.

Delivery
Help between doses

Reach your care team with questions about dosing, side effects, or your progress; support is part of the program.

Support
Transparent monthly pricing

One flat rate covers your plan. No surprise fees, no insurance runaround.

Pricing

Frequently Asked Questions

What does NAD+ do in the body?

NAD+ is a coenzyme found in every cell. It powers mitochondrial energy production, supports DNA repair, and activates sirtuins; enzymes linked to cellular aging. NAD+ levels decline with age, and supplementation is believed to support cellular energy, metabolic function, and recovery.

NAD+ is given as subcutaneous or intramuscular injection, or as an intravenous (IV) infusion for higher doses. Your provider will choose the route and dose based on your goals and tolerance. IV infusions are typically slower to minimize side effects such as flushing or muscle cramps.

Effects vary. Some people report improvements in energy, mental clarity, and recovery within weeks. NAD+ is not FDA-approved, and individual responses vary widely. Consistent therapy over 1 to 3 months is typical for assessing meaningful benefit.

No. Oral supplements such as NMN and NR are NAD+ precursors that your body converts. Injectable and IV NAD+ deliver the coenzyme more directly. Research is ongoing about which approach is most effective for different goals.

Complete our online health assessment, share relevant medical history, and connect with a licensed provider. If NAD+ is appropriate, your provider will develop a personalized protocol and ship your medication or schedule your infusion.