Enclomiphene, supplied as enclomiphene citrate, is an oral non-steroidal selective estrogen receptor modulator (SERM) and the trans isomer of clomiphene citrate.
It is dispensed only as a compounded prescription medication that is not FDA-approved for any use, and any use of it in men is off-label.
All enclomiphene protocols are determined by licensed providers based on your evaluation and individual health profile to support safe and appropriate use.
Card is authorized after plan selection; you are not charged until a licensed provider approves your plan.
Don’t know your BMI? Calculate it here
Enclomiphene, supplied as enclomiphene citrate, is an oral, non-steroidal selective estrogen receptor modulator (SERM) and the trans isomer of clomiphene citrate. It is thought to act at the hypothalamus and pituitary gland, reducing the estrogen feedback signal that normally restrains the body’s own hormone signaling; unlike testosterone replacement therapy, it is not a form of testosterone and does not supply the hormone from an outside source.
Enclomiphene is typically taken once daily as compounded oral capsules in provider-specified strengths. Your licensed provider will determine whether enclomiphene is appropriate, along with the formulation and dose, based on your medical history, evaluation, and treatment goals.
Compounded enclomiphene is not FDA-approved, and no enclomiphene product has ever been approved by the FDA; a branded version, Androxal, received a Complete Response Letter in 2015 rather than an approval. The related drug clomiphene citrate (Clomid) is FDA-approved only to induce ovulation in certain women, and use in men is off-label. Compounded enclomiphene is prepared by state-licensed compounding pharmacies under Section 503A of the Federal Food, Drug, and Cosmetic Act, is not reviewed by the FDA for safety, effectiveness, or quality, and remains under FDA evaluation for compounding.
Enclomiphene is a prescription medication, not a dietary supplement, and is initiated only after a clinical evaluation by a licensed provider. As a SERM, it carries drug-class considerations, including visual disturbances, which in some cases may be prolonged, and venous blood clots; long-term safety has not been established. Not all applicants qualify. Individual results vary.
Enclomiphene (enclomiphene citrate) is an oral SERM and the trans isomer of clomiphene citrate, typically taken once daily. It is thought to act at the hypothalamus and pituitary gland, reducing estrogen feedback; in this drug class, that is associated with increased release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), the hormones that signal the testes.
Enclomiphene was studied in men during its development as the investigational drug Androxal, but the FDA issued a Complete Response Letter in 2015 rather than an approval; the available evidence comes from small, short-term studies, and long-term safety has not been established. Any use of enclomiphene in men is off-label, weighed against SERM drug-class risks by a licensed provider.
Important Safety Information Tap to read ▾
Warning: Visual Disturbances and Blood Clots Selective estrogen receptor modulators such as enclomiphene have been associated with visual disturbances (blurring, spots, or flashes), which in some cases may be prolonged, and with venous blood clots, which have also been reported in men taking clomiphene. Stop enclomiphene and contact your provider promptly if you notice any change in your vision.
Do not use enclomiphene if you:
Tell your provider before starting enclomiphene if you:
Common side effects may include: headache, nausea, hot flashes, and mood changes.
Serious but less common risks may include: visual disturbances, which in some cases may be prolonged, and venous blood clots such as deep vein thrombosis or pulmonary embolism.
This is not a complete list of side effects or contraindications. Enclomiphene should be used only under the ongoing supervision of a licensed provider. Compounded enclomiphene is not FDA-approved. Talk to a licensed healthcare provider before starting or continuing enclomiphene.
0
Complete a short online wellness quiz so we can understand your goals, health history, and what’s right for you.
0
A healthcare provider reviews your information to determine if you qualify for prescription medication. No waiting rooms, no hassle.
0
If approved, your medication ships directly to your door in as little as 1–2 days; with ongoing support to keep you on track.
Every plan is reviewed by a licensed healthcare provider before medication is dispensed.
Medication arrives in discreet packaging on a consistent schedule; no pharmacy trips required.
Reach your care team with questions about dosing, side effects, or your progress; support is part of the program.
One flat rate covers your plan. No surprise fees, no insurance runaround.
Enclomiphene is considered only after a clinical evaluation by a licensed provider, typically when morning blood tests and symptoms suggest low testosterone with intact pituitary signaling. Because it is off-label and not appropriate for everyone, your provider will review your labs, symptoms, and medical history before deciding whether to prescribe it.
Enclomiphene is taken by mouth, typically once daily, as compounded oral capsules in provider-specified strengths. Dosing is individualized, usually starting low and adjusting over time based on your lab work, response, and your provider’s ongoing monitoring.
Response varies and is not guaranteed. Providers generally recheck lab work within the first few months and adjust or discontinue therapy based on your results, symptoms, and goals. Individual results vary, and long-term data on enclomiphene are limited.
Enclomiphene is not a form of testosterone and does not supply a hormone from an outside source. In the small, short-term studies available it was not associated with the sperm suppression seen with testosterone replacement, but fertility outcomes are not established and data are limited. Always discuss family-planning goals with your provider.
Complete our online health assessment, upload recent lab results if available, and connect with a licensed provider. If a provider determines treatment is appropriate, your personalized plan and medication ship directly to your door.
