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Nicotinamide (a form of vitamin B3 and a NAD+ precursor) is among the most evidence-supported topical skincare ingredients. It is known to improve skin barrier function, reduce transepidermal water loss, modulate pigmentation, and reduce the appearance of fine lines and erythema with consistent use. Topical NAD+ itself has more limited clinical data, but the underlying premise is that supporting cellular NAD+ pools in the skin may aid cellular energy and repair processes.
Formulation matters: topical peptides and NAD+ precursors work best in stable, well-preserved bases that allow the active ingredient to penetrate the stratum corneum. Consistent daily use for at least 8–12 weeks is typically needed before visible improvements are expected.
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Complete a short online wellness quiz so we can understand your goals, health history, and what’s right for you.
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A healthcare provider reviews your information to determine if you qualify for prescription medication. No waiting rooms, no hassle.
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If approved, your medication ships directly to your door in as little as 1–2 days; with ongoing support to keep you on track.
Every plan is reviewed by a licensed healthcare provider before medication is dispensed.
Medication arrives in discreet packaging on a consistent schedule; no pharmacy trips required.
Reach your care team with questions about dosing, side effects, or your progress; support is part of the program.
One flat rate covers your plan. No surprise fees, no insurance runaround.
The cream combines NAD+ or its precursor nicotinamide with supporting skin-barrier ingredients. Topical nicotinamide is well-studied for improving skin barrier function, reducing fine lines and redness, and evening skin tone. Consistent daily use for 8 to 12 weeks is typically needed for visible improvements.
Apply to clean skin once or twice daily; typically morning and evening. A pea-sized amount for the full face is sufficient. Follow with your moisturizer and, in the morning, a broad-spectrum sunscreen. Avoid the immediate eye area unless the product is formulated for it.
Yes. Nicotinamide is generally well-tolerated with most active ingredients, including retinoids and vitamin C. If you’re using strong acids or retinoids, start slowly and monitor for irritation.
Topical nicotinamide is generally considered low-risk during pregnancy, but discuss any skincare product with your OB or midwife. Avoid combining with retinoids during pregnancy.
Add NAD+ Face Cream to your cart; no prescription required for the cream. Pair with consistent daily sunscreen and a gentle cleansing routine for best results. Visible improvements are typical after 8 to 12 weeks.
