Sermorelin

Natural Growth Hormone Support
Sermorelin is used to stimulate the body’s natural production of growth hormone through its regulatory pathways. Rather than replacing hormones, it works with the body’s signaling system to support recovery, sleep quality, and overall physiological balance. This approach is often preferred for individuals seeking a more natural, regulated method of supporting growth hormone activity over time.
Subscription Plan $299 / every 4 weeks
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Card is authorized after plan selection; you are not charged until a licensed provider approves your plan.

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A Deeper Look Inside Sermorelin

What is Sermorelin?

Sermorelin is a synthetic analog of the first 29 amino acids of growth hormone-releasing hormone (GHRH). Rather than supplying growth hormone directly, sermorelin stimulates the pituitary gland to produce and release the body’s own growth hormone in a pulsatile, physiologic pattern. It is used clinically for adult growth hormone deficiency and off-label in longevity, metabolic, and recovery programs under medical supervision. Sermorelin is administered as a daily subcutaneous injection, typically at bedtime to align with the body’s natural GH pulse. Your provider will tailor the dose and duration to your labs (IGF-1), age, and goals. Compounded sermorelin is not FDA-approved for adult use. Geref® (sermorelin acetate) was previously FDA-approved for pediatric growth-hormone deficiency diagnosis and treatment but is no longer commercially available. Compounded sermorelin is prepared by state-licensed compounding pharmacies under Section 503A of the Federal Food, Drug, and Cosmetic Act. A valid prescription from a licensed healthcare provider is required. Not all applicants qualify. Individual results vary.

The Science

Growth hormone (GH) is secreted by the anterior pituitary in response to GHRH from the hypothalamus. GH stimulates the liver to produce insulin-like growth factor 1 (IGF-1), which mediates many of GH’s anabolic and metabolic effects; including protein synthesis, lipolysis, glucose regulation, and tissue repair. GH and IGF-1 decline with age, a phenomenon sometimes called somatopause.

Sermorelin works upstream of GH by stimulating the body’s own pituitary release. Because it relies on an intact pituitary and preserves the physiologic negative-feedback loop, sermorelin is considered less likely to cause excessive GH elevation than direct recombinant human growth hormone (rhGH) administration. Long-term safety data for compounded sermorelin in healthy adults are limited.

Important Safety Information
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Do not use sermorelin if you:

  • Have an active malignancy or history of cancer
  • Have hypersensitivity to sermorelin or mannitol
  • Are pregnant or breastfeeding
  • Have severe illness or acute critical care needs
  • Have had a recent surgical or trauma event with respiratory failure

Tell your provider before starting sermorelin if you:

  • Have diabetes or impaired glucose tolerance
  • Have thyroid disease
  • Have a history of cancer or a first-degree relative with cancer
  • Have intracranial lesion or pituitary disease
  • Take corticosteroids or medications that affect growth hormone

Common side effects may include: injection-site redness, pain, or swelling; flushing; headache; dizziness; nausea; drowsiness; hyperactivity; pallor; transient tachycardia.

Serious but less common risks may include: hypersensitivity reaction, worsening of existing malignancy, glucose intolerance, adrenal insufficiency, and paradoxical effects in patients with primary pituitary disease.

This is not a complete list of side effects or contraindications. Compounded sermorelin is not FDA-approved for adult use. Periodic IGF-1 and glucose monitoring is recommended. Talk to a licensed healthcare provider before starting or continuing sermorelin.

How Revive Longevity Works

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Submit Your Application

Complete a short online wellness quiz so we can understand your goals, health history, and what’s right for you.

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Connect with a Licensed Provider

A healthcare provider reviews your information to determine if you qualify for prescription medication. No waiting rooms, no hassle.

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Begin Your Wellness Journey

If approved, your medication ships directly to your door in as little as 1–2 days; with ongoing support to keep you on track.

Why members choose Revive

Provider-reviewed plans

Every plan is reviewed by a licensed healthcare provider before medication is dispensed.

Medical oversight
Shipped to your door

Medication arrives in discreet packaging on a consistent schedule; no pharmacy trips required.

Delivery
Help between doses

Reach your care team with questions about dosing, side effects, or your progress; support is part of the program.

Support
Transparent monthly pricing

One flat rate covers your plan. No surprise fees, no insurance runaround.

Pricing

Frequently Asked Questions

How does sermorelin differ from HGH?

Sermorelin is a growth hormone-releasing hormone (GHRH) analog that stimulates your pituitary to release its own growth hormone in a natural, pulsatile pattern. Synthetic human growth hormone (rhGH) directly supplies the hormone. Sermorelin preserves the body’s feedback loop, which many providers consider a more physiologic approach.

Sermorelin has been used clinically for decades, primarily for pediatric growth-hormone deficiency. Long-term safety data in healthy adults for longevity purposes are limited. Your provider will periodically monitor IGF-1 levels and overall health to guide duration of therapy.

Most people notice improvements in sleep quality and recovery within the first few weeks. Changes in body composition, energy, and skin quality typically take 3 to 6 months of consistent nightly dosing.

Sermorelin is contraindicated in individuals with active cancer, uncontrolled thyroid conditions, intracranial lesions, or during pregnancy and breastfeeding. Your provider will screen for these before initiating therapy.

Complete our online health assessment, share any recent IGF-1 or hormone labs, and connect with a licensed provider. If sermorelin is appropriate, your provider will develop a personalized protocol and ship your medication.